Opportunity Information: Apply for RFA NS 23 008
The NIH StrokeNet National Data Management Center (NDMC) 2023 opportunity (RFA-NS-23-008) is a National Institutes of Health (NIH) cooperative agreement (U01; clinical trials not allowed) that funds a single organization to serve as the central data hub for the NIH Stroke Trials Network. StrokeNet, established by the National Institute of Neurological Disorders and Stroke (NINDS) in 2013, is designed to speed up and improve the quality of stroke research by providing a standardized, network-wide infrastructure for developing and running rigorous, multi-site studies. The overall program goal is to maximize efficiency and quality in testing promising interventions across the full stroke continuum, with an intentional balance between stroke prevention, acute treatment, and recovery/rehabilitation research.
This FOA focuses specifically on the NDMC role within StrokeNet. In practical terms, the NDMC is expected to centralize, harmonize, and coordinate all aspects of data collection and data management for studies conducted through the network. That includes building and maintaining consistent systems and processes so that data coming from many hospitals and study teams can be collected in a uniform way, checked for quality, managed securely, and made usable for analysis and reporting. Because StrokeNet supports complex, multi-site efforts, the NDMC is positioned as the backbone for reliable trial and study operations from a data standpoint, ensuring that the network can run studies efficiently while maintaining high standards for accuracy, completeness, and consistency.
The NDMC does not operate in isolation. StrokeNet studies are coordinated through a National Coordinating Center (NCC), the NDMC, and multiple Regional Coordinating Stroke Centers (RCCs). These entities work together across a wide range of stroke-relevant clinical specialties, reflecting how stroke care and research actually happen in real-world settings. The network infrastructure is built to support collaboration among vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology, allowing StrokeNet to run studies that may span acute emergency workflows, inpatient management, imaging, procedures, and long-term functional outcomes.
The scientific scope of the network includes multi-site exploratory studies and confirmatory Phase 3 clinical trials, along with biomarker validation studies that are immediately preparatory to trials and ancillary studies that add scientific aims to ongoing active studies. Even though this particular award mechanism is labeled "clinical trials not allowed" for the applicant organization under this FOA, the funded NDMC is intended to support the larger StrokeNet enterprise that coordinates and executes these multi-site clinical research activities. A key expectation is that the NDMC can handle collaboration not only with investigators within the StrokeNet consortium but also with investigators and industry partners outside the network, since projects may originate from many sources. That emphasis on external collaboration signals a need for strong interoperability, clear governance processes, and the ability to integrate data workflows across varied partners while still enforcing StrokeNet standards.
Eligibility is broad and includes many common U.S. applicant types such as state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); and small businesses, among others. The FOA also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. At the same time, the opportunity is explicitly limited to domestic participation: non-U.S. (foreign) institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
Administratively, this is a discretionary NIH funding opportunity in the health category (CFDA 93.853) using a cooperative agreement instrument, which typically means substantial NIH involvement in oversight and coordination compared with a standard grant. The original application due date listed is February 28, 2023. The award ceiling is stated as $1,000,000. Separate funding announcements were issued for the other major StrokeNet infrastructure pieces (the Regional Coordinating Stroke Centers and the National Coordinating Center), emphasizing that this NDMC award is one part of a larger, integrated national network designed to deliver consistent, high-quality stroke research operations at scale.Apply for RFA NS 23 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH StrokeNet National Data Management Center for year 2023 (U01 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on 2022-12-15.
- Applicants must submit their applications by 2023-02-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH StrokeNet National Data Management Center (NDMC) 2023 (RFA-NS-23-008)
What is this funding opportunity?
This opportunity (RFA-NS-23-008) is a National Institutes of Health (NIH) cooperative agreement (U01) to fund a single organization to serve as the NIH StrokeNet National Data Management Center (NDMC), the central data hub for the NIH Stroke Trials Network (StrokeNet).
Which NIH Institute is associated with StrokeNet?
StrokeNet was established by the National Institute of Neurological Disorders and Stroke (NINDS) in 2013.
What does StrokeNet exist to do?
StrokeNet is designed to speed up and improve the quality of stroke research by providing a standardized, network-wide infrastructure for developing and running rigorous, multi-site studies.
What is the overall program goal of StrokeNet?
The program goal is to maximize efficiency and quality in testing promising interventions across the full stroke continuum, balancing research in stroke prevention, acute treatment, and recovery/rehabilitation.
What is the NDMC's role within StrokeNet?
The NDMC is expected to centralize, harmonize, and coordinate all aspects of data collection and data management for studies conducted through the StrokeNet network.
What kinds of data responsibilities are included for the NDMC?
Based on the description provided, the NDMC is responsible for building and maintaining consistent systems and processes so data from many hospitals and study teams can be collected uniformly, checked for quality, managed securely, and made usable for analysis and reporting.
Why is the NDMC described as the backbone of network operations?
Because StrokeNet runs complex multi-site efforts, the NDMC supports reliable study operations from a data standpoint by helping ensure efficiency and high standards for data accuracy, completeness, and consistency across the network.
Does the NDMC operate independently?
No. StrokeNet studies are coordinated through multiple components: a National Coordinating Center (NCC), the NDMC, and multiple Regional Coordinating Stroke Centers (RCCs). These entities work together to support network studies.
What other StrokeNet infrastructure components are mentioned?
The opportunity notes that separate funding announcements were issued for the Regional Coordinating Stroke Centers (RCCs) and the National Coordinating Center (NCC), and that the NDMC award is one part of a larger integrated national network.
What clinical and research specialties does StrokeNet support?
The network infrastructure is built to support collaboration across vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology.
What kinds of studies are within the scientific scope of StrokeNet?
The network scope includes multi-site exploratory studies, confirmatory Phase 3 clinical trials, biomarker validation studies that are immediately preparatory to trials, and ancillary studies that add scientific aims to ongoing active studies.
If StrokeNet supports clinical trials, why does this FOA say "clinical trials not allowed"?
This FOA is described as a U01 mechanism with "clinical trials not allowed" for the applicant organization under this announcement, while still intending the funded NDMC to support the broader StrokeNet enterprise that coordinates and executes multi-site clinical research activities across the network.
How important is collaboration with organizations outside StrokeNet?
The NDMC is expected to be able to collaborate with investigators within the StrokeNet consortium and also with investigators and industry partners outside the network, since projects may originate from many sources.
What does the emphasis on external collaboration imply for the NDMC?
The description highlights needs such as strong interoperability, clear governance processes, and the ability to integrate data workflows across varied partners while enforcing StrokeNet standards.
What is the funding instrument type for this opportunity?
It is a cooperative agreement (U01), which typically involves substantial NIH involvement in oversight and coordination compared with a standard grant.
Is this a discretionary funding opportunity?
Yes. It is described as a discretionary NIH funding opportunity.
What is the program or category for this opportunity?
It is in the health category and is associated with CFDA 93.853.
How many awards are expected under this FOA?
The opportunity funds a single organization to serve as the NDMC.
What is the award ceiling?
The award ceiling is stated as $1,000,000.
What was the application due date listed?
The original application due date listed is February 28, 2023.
Who is eligible to apply?
Eligibility is broad and includes (among others) state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); and small businesses.
Are minority-serving institutions and other special categories mentioned as eligible?
Yes. The FOA highlights eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also mentions faith-based or community-based organizations, eligible federal agencies, and other eligible applicant categories.
Are foreign (non-U.S.) institutions eligible to apply?
No. The opportunity is limited to domestic participation: non-U.S. (foreign) institutions are not eligible to apply.
Can a U.S. organization include non-domestic components?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this opportunity?
No. Foreign components, as defined by NIH policy, are not allowed.
What part of the stroke continuum is intended to be covered by network research?
The network is intended to support an intentional balance across stroke prevention, acute treatment, and recovery/rehabilitation research.
What is the practical impact of having a centralized NDMC for multi-site studies?
As described, a centralized NDMC supports uniform data collection across sites, consistent quality checks, secure management, and reliable datasets for analysis and reporting, which helps multi-site studies run efficiently while maintaining high data standards.
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