Opportunity Information: Apply for PAR 23 085
The Genomic Community Resources (U24 Clinical Trial Not Allowed) opportunity (PAR-23-085) is a National Institutes of Health funding announcement from the National Human Genome Research Institute (NHGRI) designed to strengthen the shared infrastructure that underpins modern genomics. The core idea is to fund community-facing resources that make genomic research easier, cheaper, more standardized, and more broadly usable by many investigators rather than serving only a single lab or narrow project. The mechanism is a U24 cooperative agreement, which typically means NIH staff will have substantial involvement in shaping priorities, milestones, and coordination, reflecting the expectation that these resources operate as national or international community assets rather than as purely investigator-directed research projects.
The resources targeted by this program are practical, reusable products that accelerate discovery across basic biology, human disease research, model organism work, and other biomedical applications. NHGRI is explicitly interested in development and distribution of genomic resources that rely on cost-effective approaches and that deliver high value to a broad research community. Examples called out include databases and informatics resources such as human and model organism databases, ontologies that standardize how genomic concepts are defined and linked, and analysis toolsets that help researchers interpret or integrate genomic data. The program also supports comprehensive identification and curated collections of genomic features, such as functional genomic elements, as well as standardized data types generated from central, well-characterized sample sets. Illustrative examples of the latter include community reference resources similar in spirit to structural variant catalogs built from 1000 Genomes samples or tissue-based reference data comparable to GTEx, where standardized sampling and processing enable wide downstream reuse and benchmarking.
Because this is labeled “Clinical Trial Not Allowed,” it is meant for resource development rather than interventional clinical studies. In practice, applicants should be oriented toward building, scaling, maintaining, and distributing tools, datasets, standards, and platforms that other researchers will rely on, with an emphasis on accessibility, usability, and broad impact. Successful projects in this space typically include clear plans for data dissemination, user support and documentation, interoperability with existing community standards, and ongoing updates or maintenance so the resource remains current and trustworthy. The cooperative agreement structure also implies an expectation of coordination with NHGRI and, often, with other related efforts in the field to reduce duplication and improve harmonization.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants listed include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, Indian/Native American tribal governments that are not federally recognized, and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility reflects NHGRI’s focus on community benefit and the reality that high-impact genomic resources can be built and hosted by many kinds of institutions.
From the provided source data, the opportunity is categorized as discretionary funding and falls under education, environment, and health activity categories, with CFDA numbers 93.113, 93.172, and 93.399. The original closing date listed is January 25, 2023, and the posting creation date is December 22, 2022. Award ceiling and expected number of awards are not specified in the provided excerpt, which is common for resource-focused FOAs where budgets can vary widely depending on scope, scale, and deliverables.
Overall, this FOA is aimed at building the shared genomic “public goods” that many researchers depend on: curated databases, standards and ontologies, analysis and integration tools, reference-quality catalogs of genomic features, and widely reusable datasets generated in a consistent way. The emphasis is on cost-effective production, broad distribution, and sustained value to the larger genomics community, with NIH involvement typical of cooperative agreements to help ensure the resulting resources align with community needs and remain widely usable.Apply for PAR 23 085
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Genomic Community Resources (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.172, 93.399.
- This funding opportunity was created on 2022-12-22.
- Applicants must submit their applications by 2023-01-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Genomic Community Resources (U24 Clinical Trial Not Allowed) (PAR-23-085)
What is the Genomic Community Resources (U24 Clinical Trial Not Allowed) opportunity (PAR-23-085)?
PAR-23-085 is a National Institutes of Health (NIH) funding announcement from the National Human Genome Research Institute (NHGRI). It supports the development, scaling, maintenance, and distribution of community-facing genomic resources that many researchers can use, rather than tools or datasets built for a single lab or narrow project.
What is the main goal of this funding opportunity?
The goal is to strengthen the shared infrastructure that underpins modern genomics by funding practical, reusable resources that make genomic research easier, cheaper, more standardized, and more broadly usable across the research community.
Which NIH Institute is sponsoring this opportunity?
This opportunity is sponsored by the National Human Genome Research Institute (NHGRI) within NIH.
What does the U24 cooperative agreement mechanism mean for applicants?
The award mechanism is a U24 cooperative agreement. In general, this structure means NIH staff are expected to have substantial involvement in shaping priorities, milestones, and coordination. The expectation is that funded resources function as national or international community assets, not purely investigator-directed projects.
What kinds of projects are a good fit for this FOA?
Projects that create or improve widely reusable genomic “public goods,” such as databases, standards, toolsets, reference datasets, or curated catalogs of genomic features. The emphasis is on community value, broad adoption, cost-effective approaches, and sustained usability over time.
What types of resources are specifically mentioned as examples?
Examples called out include:
- Databases and informatics resources (including human and model organism databases)
- Ontologies that standardize genomic concepts and relationships
- Analysis toolsets that help researchers interpret or integrate genomic data
- Comprehensive identification and curated collections of genomic features (such as functional genomic elements)
- Standardized data types generated from central, well-characterized sample sets
- Community reference resources similar in spirit to structural variant catalogs built from 1000 Genomes samples
- Tissue-based reference data comparable to GTEx, where standardized sampling and processing enable broad reuse and benchmarking
Is this opportunity intended to support clinical trials?
No. The announcement is labeled “Clinical Trial Not Allowed,” meaning it is intended for resource development rather than interventional clinical studies.
What does “community-facing” mean in the context of this FOA?
“Community-facing” means the outputs are designed for broad use by many investigators. The resource should be accessible, usable, and valuable beyond the applicant’s own organization, enabling other researchers to rely on it for discovery, analysis, benchmarking, or standardization.
What research areas can benefit from the resources supported by this program?
The FOA highlights that these resources can accelerate discovery across basic biology, human disease research, model organism work, and other biomedical applications that rely on genomics.
What characteristics are emphasized for successful resource projects?
Based on the description provided, successful projects typically include:
- Clear plans for data dissemination and distribution
- User support, documentation, and usability considerations
- Interoperability with existing community standards
- Ongoing updates or maintenance so the resource remains current and trustworthy
- Coordination efforts to reduce duplication and improve harmonization with related initiatives
How important is standardization and interoperability for this opportunity?
Standardization and interoperability are central themes. The FOA highlights ontologies and standardized data types, and it emphasizes harmonization and coordination to ensure resources integrate well with broader community standards and related efforts.
Does NHGRI expect funded resources to be maintained over time?
Yes. The opportunity emphasizes sustained value to the genomics community, including ongoing updates and maintenance so the resource remains current, reliable, and widely usable.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants listed include:
- State, county, city/township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofits with and without 501(c)(3) status
- For-profit organizations other than small businesses
- Small businesses
- Non-domestic (non-U.S.) entities (foreign organizations)
Are minority-serving institutions and community-based organizations eligible?
Yes. The announcement highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), as well as faith-based or community-based organizations.
Are U.S. territories or possessions eligible to apply?
Yes. The eligibility list explicitly includes regional organizations and U.S. territories or possessions.
Are non-federally recognized tribal governments eligible?
Yes. The eligibility list includes Indian/Native American tribal governments that are not federally recognized.
Can federal agencies apply?
Yes. The announcement lists eligible federal agencies among additional eligible applicant categories.
Is this opportunity considered discretionary funding?
Yes. The provided source data categorizes the opportunity as discretionary funding.
Which activity categories does this opportunity fall under?
From the provided source data, the opportunity falls under education, environment, and health activity categories.
What CFDA numbers are associated with this funding opportunity?
The CFDA numbers listed are 93.113, 93.172, and 93.399.
What are the key dates provided for this opportunity?
The posting creation date is December 22, 2022, and the original closing date listed is January 25, 2023.
Is the award ceiling specified in the provided information?
No. The award ceiling is not specified in the provided excerpt.
Is the expected number of awards specified?
No. The expected number of awards is not specified in the provided excerpt.
Why might award size and number of awards be unspecified for a resource-focused FOA?
The provided description notes that this is common for resource-focused funding opportunities, where budgets can vary widely depending on the scope, scale, and deliverables of the proposed resource.
What does NHGRI mean by cost-effective approaches and “high value” resources?
Within the context provided, NHGRI is interested in resources developed and distributed using cost-effective approaches that deliver broad utility to the community, enabling widespread reuse and accelerating research across many projects and investigators.
How does coordination with NHGRI and other efforts typically show up in a U24?
The cooperative agreement structure implies coordination with NHGRI and often with related efforts in the field, with the aim of reducing duplication, aligning priorities, and improving harmonization so the resource fits community needs and remains widely usable.
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| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 004 Funding Number: RFA ES 23 004 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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| CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed) Apply for PAR 23 139 Funding Number: PAR 23 139 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 23 001 Funding Number: RFA ES 23 001 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,000,000 |
| STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed) Apply for PAR 23 144 Funding Number: PAR 23 144 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $250,000 |
| Tobacco Regulatory Science (R01 Clinical Trial Optional) Apply for RFA OD 23 017 Funding Number: RFA OD 23 017 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 184 Funding Number: PAR 23 184 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 011 Funding Number: RFA ES 23 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 229 Funding Number: PAR 23 229 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 23 263 Funding Number: PA 23 263 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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| Intervention Research to Improve Native American Health (R21 Clinical Trials Optional) Apply for PAR 23 299 Funding Number: PAR 23 299 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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| Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional) Apply for RFA NR 24 004 Funding Number: RFA NR 24 004 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
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