Opportunity Information: Apply for PAR 21 172
The Transition to Independent Environmental Health Research (TIEHR) Career Award is an NIH-funded K01 career development grant (PAR-21-172) designed as a three-year bridge program for newly independent faculty who are building long-term research careers in environmental health sciences. The main purpose is to help early-stage faculty strengthen their research direction, expand skills and mentorship, and generate the track record needed to compete successfully for larger, independent environmental health research funding by the end of the award period. In practical terms, the program is meant to support scholars at a critical point: after they have started a faculty appointment but before they have fully established sustained, independently funded research programs.
A key feature of this specific FOA is its clear restriction around clinical trials. It is explicitly for applicants whose proposed research does not include leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. However, the FOA does allow applicants to gain research experience within a clinical trial as long as that trial is led by a mentor or co-mentor. This structure lets candidates develop relevant translational or human-subjects research experience without taking on the role and regulatory responsibilities of being the independent clinical trial leader under this award.
From an eligibility and institutional standpoint, the opportunity is open to a range of domestic organizations, including public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both 501(c)(3) and non-501(c)(3), as long as they are not higher education institutions in those categories). The FOA also highlights eligibility for several institution types that often align with NIH efforts to broaden participation and research capacity, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and eligible federal government agencies. At the same time, it draws a firm boundary around foreign involvement: non-U.S. (non-domestic) institutions cannot apply as applicant organizations, and non-U.S. components of U.S. organizations are not eligible. That said, "foreign components" are allowed when they meet the NIH Grants Policy Statement definition, meaning certain discrete, well-justified elements of the work may occur outside the U.S. under NIH rules even though the applicant organization must be U.S.-based.
Administratively, this is a discretionary grant mechanism under NIH, with the funding activity aligned to environment and health (CFDA/Assistance Listing 93.113). The FOA was created on March 15, 2021, and the original closing date listed is May 7, 2024. The excerpted source data does not provide an award ceiling or expected number of awards, so applicants would typically need to consult the full FOA text or NIH institute-specific budget guidance to understand typical funding levels, allowable costs, and any institute payline or portfolio considerations.
Overall, the TIEHR K01 is best understood as a structured, time-limited career development runway for newly independent environmental health scientists who need dedicated support to sharpen their research niche, produce competitive outputs (publications, preliminary data, methods development), and position themselves to win independent research awards soon after the three-year period ends, while staying within the "clinical trial not allowed" boundaries for the candidate-led project.Apply for PAR 21 172
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Transition to Independent Environmental Health Research (TIEHR) Career Award (K01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2021-03-15.
- Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.
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Frequently Asked Questions (FAQs): Transition to Independent Environmental Health Research (TIEHR) K01 (PAR-21-172)
What is the TIEHR Career Award?
The Transition to Independent Environmental Health Research (TIEHR) Career Award is an NIH-funded K01 career development grant (PAR-21-172). It is designed as a three-year bridge program for newly independent faculty building long-term research careers in environmental health sciences.
What is the main purpose of this K01?
The main purpose is to help early-stage faculty strengthen their research direction, expand skills and mentorship, and build the track record needed to compete successfully for larger, independent environmental health research funding by the end of the award period.
Who is this program designed for?
It is intended for newly independent faculty at a critical career point: after starting a faculty appointment but before establishing a sustained, independently funded research program.
How long is the TIEHR K01 award period?
The program is described as a three-year bridge program.
What type of grant mechanism is this?
This opportunity uses the NIH K01 career development mechanism and is described as a discretionary grant mechanism under NIH.
What research area does this FOA focus on?
The funding activity is aligned to environment and health, and the award is framed specifically around environmental health sciences.
What is the Assistance Listing (CFDA) number for this opportunity?
The Assistance Listing (CFDA) associated with this funding activity is 93.113.
Are clinical trials allowed under this FOA?
No. A key restriction is that the proposed research must not include leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial.
Can an applicant participate in a clinical trial at all?
Yes. The FOA allows applicants to gain research experience within a clinical trial, as long as the clinical trial is led by a mentor or co-mentor. This allows candidates to build translational or human-subjects research experience without serving as the independent clinical trial leader under this award.
Why does the FOA allow clinical trial experience but not a candidate-led clinical trial?
Based on the description provided, this structure lets candidates obtain relevant clinical trial or human-subjects experience while avoiding the role and regulatory responsibilities of being the independent clinical trial leader under the K01 candidate-led project.
What types of U.S. organizations are eligible to apply?
The opportunity is open to a range of domestic organizations, including public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both 501(c)(3) and non-501(c)(3), as long as they are not higher education institutions in those categories).
Are minority-serving institutions and similar institution types eligible?
Yes. The FOA highlights eligibility for several institution types often aligned with NIH efforts to broaden participation and research capacity, including:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
Are federal government agencies eligible to apply?
Yes. Eligible federal government agencies are explicitly listed among eligible applicant organization types.
Can a non-U.S. (foreign) institution apply as the applicant organization?
No. Non-U.S. (non-domestic) institutions cannot apply as the applicant organization for this opportunity.
Are non-U.S. components of a U.S. organization eligible?
No. Non-U.S. components of U.S. organizations are not eligible, according to the description provided.
Are any foreign activities allowed at all?
Yes, in a limited way. "Foreign components" are allowed when they meet the NIH Grants Policy Statement definition, meaning certain discrete and well-justified elements of the work may occur outside the U.S. under NIH rules, even though the applicant organization must be U.S.-based.
What does "foreign component" mean in this context?
Only the definition referenced in the description is available: a foreign component is allowable if it meets the NIH Grants Policy Statement definition and represents a discrete, well-justified element of work occurring outside the U.S. while the applicant organization remains U.S.-based.
When was this FOA created?
The FOA was created on March 15, 2021.
What is the closing date listed for this opportunity?
The original closing date listed is May 7, 2024.
Does the provided information include an award ceiling or the expected number of awards?
No. The excerpted source data does not provide an award ceiling or expected number of awards.
Where should applicants look for typical funding levels and allowable costs?
Based on the information provided, applicants would typically need to consult the full FOA text or NIH institute-specific budget guidance to understand typical funding levels, allowable costs, and related considerations.
What outcomes is the TIEHR K01 intended to support by the end of the three-year period?
The program is intended to help scholars sharpen their research niche and produce competitive outputs such as publications, preliminary data, and methods development, positioning them to win independent research awards soon after the three-year period ends.
How should applicants think about the overall role of the TIEHR K01 in a career path?
It is best understood as a structured, time-limited career development runway for newly independent environmental health scientists who need dedicated support to strengthen their research trajectory and become competitive for larger independent funding, while staying within the FOA's clinical trial restrictions.
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| CCRP Initiative: Chemical Threat Agent-induced Pulmonary and Ocular Pathophysiological Mechanisms (R01 Clinical Trial Not Allowed) Apply for RFA ES 21 006 Funding Number: RFA ES 21 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Innovative Approaches for Improving Environmental Health Literacy (R41/R42 Clinical Trial Not Allowed) Apply for RFA ES 21 009 Funding Number: RFA ES 21 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Innovative Approaches for Improving Environmental Health Literacy (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 21 008 Funding Number: RFA ES 21 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Maintaining and Enriching Environmental Epidemiology Cohorts to Support Scientific and Workforce Diversity (U24 Clinical Trial Not Allowed) Apply for RFA ES 22 001 Funding Number: RFA ES 22 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $250,000 |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 22 002 Funding Number: RFA ES 22 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 22 138 Funding Number: PAR 22 138 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R01-Clinical Trial Not Allowed) Apply for PAR 22 137 Funding Number: PAR 22 137 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 22 004 Funding Number: RFA ES 22 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for PAR 22 210 Funding Number: PAR 22 210 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Centers for Oceans and Human Health 4: Impacts of Climate Change on Oceans and Great Lakes (COHH4) (P01 Clinal Trial Optional) Apply for RFA ES 22 005 Funding Number: RFA ES 22 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $950,000 |
| Biological Basis for how Environmental Exposures Impact Risk for Psychiatric Disorders (R01 Clinical Trial Not Allowed) Apply for RFA ES 22 008 Funding Number: RFA ES 22 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Biological Basis for how Environmental Exposures Impact Risk for Psychiatric Disorders (R21 Clinical Trial Not Allowed) Apply for RFA ES 22 009 Funding Number: RFA ES 22 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $275,000 |
| Utilizing Telomere Status to Reveal Molecular Mechanisms Underlying Susceptibility and Resiliency in Response to Environmental Exposures (R01 Clinical Trial Not Allowed) Apply for RFA ES 22 007 Funding Number: RFA ES 22 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 22 010 Funding Number: RFA ES 22 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Accelerating Data and Metadata Standards in the Environmental Health Sciences (R24 Clinical Trial Not Allowed) Apply for RFA ES 23 002 Funding Number: RFA ES 23 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Maintaining and Enriching Environmental Epidemiology Cohorts to Support Scientific and Workforce Diversity (U24 Clinical Trial Not Allowed) Apply for RFA ES 23 003 Funding Number: RFA ES 23 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 23 005 Funding Number: RFA ES 23 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Strategies for Responsibly Reporting Back Environmental Health and Non-Genomic Research Results (R01 Clinical Trial Optional) Apply for RFA ES 23 006 Funding Number: RFA ES 23 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: Chemical Threat Agent Exposure Resource and Coordination Core (ExRC) (U2C Clinical Trial Not Allowed) Apply for RFA ES 23 009 Funding Number: RFA ES 23 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $750,000 |
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