Opportunity Information: Apply for RFA AI 20 023
The Limited Competition: International Epidemiology Databases to Evaluate AIDS (IeDEA) funding opportunity (RFA AI 20 023) is a National Institutes of Health (NIH) cooperative agreement (U01; clinical trial not allowed) aimed at continuing the long-running IeDEA program, which supports large-scale, multi-country HIV epidemiology and outcomes research through coordinated regional data centers. IeDEA is structured around seven regional awards that function as data hubs, bringing together and harmonizing clinical and research data from participating sites within their regions. The overall purpose is to strengthen the evidence base that informs and improves the ongoing response to the HIV/AIDS epidemic, not only by tracking trends in HIV care and outcomes, but also by enabling deeper analyses of how HIV and its treatment affect health over the long term.
A central focus of the program is the creation, maintenance, and use of robust regional databases that combine information collected through routine clinical care, public health surveillance, and formal research protocols. These datasets are designed to support analyses that answer practical, high-impact questions about HIV across diverse real-world settings. The FOA emphasizes research on the long-term impact of HIV infection and antiretroviral therapy, including how treatment over time influences survival, disease progression, and broader health status. It also highlights the importance of studying common co-infections that complicate HIV care, particularly hepatitis and tuberculosis, reflecting the reality that many people living with HIV face overlapping infectious disease burdens that shape outcomes and resource needs.
Beyond infectious complications, the opportunity underscores a wide range of chronic and systemic issues increasingly relevant as people with HIV live longer. IeDEA-supported research is expected to evaluate health care utilization patterns, including the use of medications, clinical procedures, and vaccines, which can shed light on access, quality of care, and cost-related dynamics. The FOA also calls attention to comorbidities such as cancer and to disruptions in physiological and metabolic processes that can contribute to end-organ impairment. In practical terms, this can include studying cardiovascular, renal, hepatic, and metabolic complications in the context of long-term HIV infection and sustained treatment exposure. Mental health and the impacts of alcohol and substance use are also included as priority areas, recognizing their strong links to adherence, retention in care, and overall health outcomes.
A notable component described in the announcement is the Sentinel Research Network, which complements routine data sources by collecting more intensive prospective cohort data. This is intended to improve the program's ability to study non-communicable diseases among people living with HIV and to support stronger cross-network comparisons and inferences. In other words, while much of IeDEA draws strength from very large observational datasets, the sentinel cohort approach provides richer, more standardized measurements that help answer questions that routine clinical records alone may not fully capture.
The FOA also introduces an explicit expectation that IeDEA will include a cohort of people with tuberculosis to evaluate TB treatment outcomes. This addition signals a priority to generate clearer evidence on TB care trajectories and outcomes, which is critical in many regions where TB remains a leading cause of illness and death among people with HIV. By embedding TB outcome evaluation within the broader IeDEA infrastructure, the program can potentially support large, comparative analyses across settings and help identify factors linked to successful treatment, loss to follow-up, relapse, drug resistance concerns, or mortality.
Finally, the opportunity stresses IeDEA's role as a data access and data tools resource for stakeholders at multiple levels, including clinics, national programs, and global decision-makers. The program is positioned not only to conduct analyses internally, but also to facilitate responsible data sharing, collaboration with "data consumers," and the creation of tools that make complex data more usable for public health action and policy. Eligibility for this limited competition is restricted to public and state-controlled institutions of higher education. The agency is the U.S. Department of Health and Human Services (HHS), NIH. The FOA anticipated seven awards, aligned with the seven regional data centers, and used a cooperative agreement mechanism, meaning NIH is expected to have substantial scientific and programmatic involvement in guiding activities.Apply for RFA AI 20 023
- The Department of Health and Human Services, National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Limited Competition: International Epidemiology Databases to Evaluate AIDS (IeDEA) (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.273, 93.279, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.847, 93.855, 93.865, 93.989.
- This funding opportunity was created on Apr 08, 2020.
- Applicants must submit their applications by Aug 04, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA AI 20 023) also looked into and applied for these:
| Funding Opportunity |
|---|
| Support of Competitive Research (SCORE) Research Advancement Award (SC1) Apply for PAR 16 439 Funding Number: PAR 16 439 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $250,000 |
| NIH Health Care Systems Research Collaboratory - Demonstration Projects for Pragmatic Clinical Trials (UG3/UH3) Apply for RFA RM 16 019 Funding Number: RFA RM 16 019 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| Developmental Centers for AIDS Research (P30) Apply for PAR 17 238 Funding Number: PAR 17 238 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $750,000 |
| Centers for AIDS Research (P30) Apply for PAR 17 237 Funding Number: PAR 17 237 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $3,000,000 |
| Diet and Physical Activity Assessment Methodology (R21 Clinical Trial Optional) Apply for PAR 18 112 Funding Number: PAR 18 112 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Exploratory/Developmental Clinical Research Grants in Obesity (R21 Clinical Trial Optional) Apply for PA 18 104 Funding Number: PA 18 104 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 - Clinical Trial Required) Apply for PA 18 374 Funding Number: PA 18 374 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 - Clinical Trial Required) Apply for PA 18 395 Funding Number: PA 18 395 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Clinical Trial Required) Apply for PA 18 397 Funding Number: PA 18 397 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Opportunities for Collaborative Research at the NIH Clinical Center (U01 - Clinical Trial Optional) Apply for PAR 18 646 Funding Number: PAR 18 646 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY18 Administrative Supplement (Admin Supp - Clinical Trial Optional) Apply for PA 18 676 Funding Number: PA 18 676 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Exploratory/Developmental Clinical Research Grants in Obesity (R21 Clinical Trial Optional) Apply for PA 18 720 Funding Number: PA 18 720 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Rare Diseases Clinical Research Consortia (RDCRC) for Rare Diseases Clinical Research Network (U54 Clinical Trials Optional) Apply for RFA TR 18 020 Funding Number: RFA TR 18 020 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Time-Sensitive Obesity Policy and Program Evaluation (R01 Clinical Trial Not Allowed) Apply for PAR 18 854 Funding Number: PAR 18 854 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional) Apply for RFA NS 18 041 Funding Number: RFA NS 18 041 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21 Clinical Trial Not Allowed) Apply for RFA NS 18 042 Funding Number: RFA NS 18 042 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional) Apply for RFA NS 18 046 Funding Number: RFA NS 18 046 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) Apply for RFA NS 18 043 Funding Number: RFA NS 18 043 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Predoctoral Training in Advanced Data Analytics for Behavioral and Social Sciences Research (BSSR) - Institutional Research Training Program [T32] Apply for RFA OD 19 011 Funding Number: RFA OD 19 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA NS 19 010 Funding Number: RFA NS 19 010 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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