Ending the HIV Epidemic in the U.S. – Ryan White HIV/AIDS Program Parts A and B | HRSA 25 063

Opportunity Information: Apply for HRSA 25 063

The Health Resources and Services Administration (HRSA) funding opportunity HRSA-25-063, titled "Ending the HIV Epidemic in the U.S. - Ryan White HIV/AIDS Program (RWHAP) Parts A and B," is a discretionary cooperative agreement designed to concentrate HIV resources where the epidemic is most severe. The initiative targets 48 high-burden counties plus Washington, D.C. and San Juan, Puerto Rico, along with seven states identified as having a substantial rural HIV burden. The overall aim is to reduce new HIV infections in the United States by supporting effective, data-driven, and locally tailored strategies that improve HIV diagnosis, treatment outcomes, prevention, and outbreak response in the communities most impacted.

This opportunity sits under the broader federal "Ending the HIV Epidemic" (EHE) initiative, which is organized around four core strategies. First, it emphasizes diagnosing people with HIV as early as possible, because earlier diagnosis helps individuals start treatment sooner and reduces onward transmission. Second, it prioritizes rapid and effective treatment to achieve sustained viral suppression, which improves health outcomes and prevents sexual transmission when viral load is suppressed. Third, it supports prevention approaches that are already proven to work, strengthening the tools and services that stop new transmissions. Fourth, it focuses on responding quickly to potential HIV outbreaks so prevention and treatment resources can be deployed rapidly to the people and places that need them most.

HRSA leads the parts of EHE that connect testing, care, and treatment access through the Ryan White HIV/AIDS Program and the Health Center Program. In practical terms, HRSA-funded work under this announcement is expected to increase HIV testing and prevention among health center patients, strengthen pathways into HIV medical care, and ensure that people who are newly diagnosed or "re-identified" through testing programs are linked to treatment without delay. Another central responsibility described in the opportunity is outbreak response, meaning the capacity to identify emerging clusters and rapidly connect affected individuals to prevention and care services, rather than allowing transmission to accelerate.

Within the Ryan White HIV/AIDS Program specifically, the EHE investment is described as an expansion of the program's ability to meet client needs, with a very explicit focus on improving linkage to care and viral suppression. The funding is meant to help jurisdictions find and engage three key groups: people who are newly diagnosed with HIV, people who were diagnosed previously but are not currently in care, and people who are in care but have not yet achieved viral suppression. The expectation is that recipients will use the added resources to connect these individuals to the essential mix of HIV medical care, treatment, and support services that make it possible to stay in care and reach sustained viral suppression.

Eligibility is tightly tied to the geography and existing RWHAP award structure. For Part A, eligible applicants include RWHAP Part A-funded Eligible Metropolitan Areas (EMAs) or Transitional Grant Areas (TGAs) whose service areas include one or more of the identified 48 high-burden counties, as well as the EMAs of Washington, D.C. and San Juan, Puerto Rico. For Part B, eligibility includes the states and territories identified as having substantial rural HIV burden: Alabama, Arkansas, Kentucky, Mississippi, Missouri, Oklahoma, and South Carolina. The notice also specifies the RWHAP Part B program of the State of Ohio, applying on behalf of Hamilton County. In general, applicants must be domestic organizations, with "domestic" defined broadly to include the 50 states, D.C., Puerto Rico, U.S. territories, and several Pacific jurisdictions named in the announcement.

Operationally, this is a cooperative agreement rather than a standard grant, which typically signals a more active federal role in the project through substantial involvement, collaboration, or technical direction during implementation. The opportunity is listed under CFDA 93.686 and is categorized under the health funding activity area. The announcement anticipates 47 awards. The posting indicates an application closing date of October 22, 2024. The award ceiling is shown as 0 in the provided source data, which usually means a specific ceiling was not listed in that field rather than implying that funding is unavailable; applicants generally need to consult the full notice for budget parameters and expected award sizes.

Finally, the opportunity is explicitly framed as part of a multi-agency EHE effort. HRSA is described as working in coordination with the Centers for Disease Control and Prevention (CDC) and other federal partners including NIH Centers for AIDS Research (CFARs), the Indian Health Service (IHS), the Department of Housing and Urban Development (HUD), and the Substance Abuse and Mental Health Services Administration (SAMHSA). The intent is to align clinical care, public health surveillance and prevention, research capacity, housing supports, and behavioral health and substance use services so that high-burden jurisdictions can move faster toward fewer new infections, stronger linkage to care, and higher viral suppression rates.

• The Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Ending the HIV Epidemic in the U.S. – Ryan White HIV/AIDS Program Parts A and B" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.686.
• This funding opportunity was created on 2024-08-22.
• Applicants must submit their applications by 2024-10-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 47 candidate(s).
• Eligible applicants include: Others.

Apply for HRSA 25 063

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: