Opportunity Information: Apply for W81XWH 18 TSCRP CTRA
The DoD Tuberous Sclerosis Complex Clinical Translational Research Award (funding opportunity number W81XWH 18 TSCRP CTRA) is a Department of Defense research funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is intended to accelerate meaningful progress in tuberous sclerosis complex (TSC) by supporting clinical and translational research that deliberately connects laboratory discovery and patient-focused investigation. The central idea is a two-way, iterative exchange between basic science and clinical science, where findings in one setting directly shape questions, methods, and next steps in the other, with the end goal of improving how TSC is diagnosed, how outcomes are predicted (prognosis), and how the condition is treated.
This program specifically encourages projects that move in either direction along the translational pipeline. On the "forward" side, it can support studies that take promising preclinical results and advance them toward clinical research, including a pilot clinical trial when appropriate. On the "reverse" side, it can support efforts that start from human clinical observations and data, such as analyzing patient specimens (human anatomical substances) and datasets generated in the context of clinical trials, including correlative studies. These human-derived insights are then used to build or refine experimental models that better mirror real clinical outcomes, helping researchers test hypotheses and interventions in ways that are more likely to translate back to patient benefit.
From an administrative and eligibility standpoint, the opportunity falls under the Science and Technology and other Research and Development category and is listed under CFDA number 12.420. The funding can be provided as either a cooperative agreement or a grant, meaning applicants may need to be prepared for varying levels of government involvement depending on the award structure used. Eligibility is listed as unrestricted, which generally means applications may be submitted by a broad range of organization types, assuming no additional limitations are specified elsewhere in the full announcement. The opportunity was originally posted on May 14, 2018, with an original closing date of August 2, 2018, and it anticipated making two awards. The listing shows an award ceiling of 0, which typically indicates that a specific maximum amount was not provided in the summary field and would need to be confirmed in the full solicitation details.
Overall, the award is geared toward well-justified translational projects that can demonstrate a clear feedback loop between clinical realities in TSC and mechanistic or model-based research, while keeping a strong line of sight to practical improvements in patient care.Apply for W81XWH 18 TSCRP CTRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex Clinical Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 14, 2018.
- Applicants must submit their applications by Aug 02, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Tuberous Sclerosis Complex (TSC) Clinical Translational Research Award (W81XWH 18 TSCRP CTRA)
What is this funding opportunity?
This is the Department of Defense (DoD) Tuberous Sclerosis Complex Clinical Translational Research Award, funding opportunity number W81XWH 18 TSCRP CTRA. It is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the main purpose of the award?
The award is intended to accelerate meaningful progress in tuberous sclerosis complex (TSC) by supporting clinical and translational research that deliberately links laboratory discovery with patient-focused investigation, with the end goal of improving TSC diagnosis, prognosis (outcome prediction), and treatment.
What type of research does this program support?
The program supports clinical and translational research designed to connect basic science and clinical science through a two-way, iterative exchange, where results from one setting directly influence the questions, methods, and next steps in the other setting.
What does "clinical translational" mean in the context of this award?
In this program, "clinical translational" means a deliberate feedback loop between clinical realities in TSC (patients, specimens, clinical data, clinical trials) and mechanistic or model-based research (laboratory studies, experimental systems), so that each side informs and improves the other and stays focused on patient benefit.
What is meant by a "two-way, iterative exchange" between basic and clinical science?
It means findings from laboratory work should shape what is studied in patients (and how), and observations from patients should shape what is tested in the lab (and how). The project should be designed so that insights continually move back and forth rather than flowing in only one direction.
Does the program only support moving from lab research to patient studies?
No. The program encourages projects that move in either direction along the translational pipeline, including both "forward" translation (preclinical to clinical) and "reverse" translation (clinical observations back to models and mechanistic studies).
What is "forward" translation under this opportunity?
"Forward" translation refers to taking promising preclinical results and advancing them toward clinical research. The opportunity notes that this can include a pilot clinical trial when appropriate.
Does this award allow pilot clinical trials?
Yes, the program description indicates it can support advancing preclinical results toward clinical research, including a pilot clinical trial when appropriate.
What is "reverse" translation under this opportunity?
"Reverse" translation refers to starting with human clinical observations and data, such as analyses of patient specimens (human anatomical substances) and datasets generated during clinical trials (including correlative studies), and then using those insights to build or refine experimental models that better reflect real clinical outcomes.
What kinds of human-derived materials or data are mentioned as relevant?
The description specifically mentions patient specimens (human anatomical substances) and datasets generated in the context of clinical trials, including correlative studies.
What are correlative studies in the context provided?
Based on the listing, correlative studies are analyses performed using datasets generated during clinical trials, aimed at relating clinical data and/or biological measures to outcomes, and using those findings to inform further research directions and model development.
What is the expected impact or end goal for funded projects?
The stated end goal is improving how TSC is diagnosed, how outcomes are predicted (prognosis), and how the condition is treated, by ensuring research maintains a clear line of sight to practical improvements in patient care.
How should applicants demonstrate that their project fits the program?
The summary emphasizes projects that can demonstrate a clear feedback loop between clinical realities in TSC and mechanistic or model-based research, and that are well-justified as translational efforts tied to patient benefit.
What category is this opportunity listed under?
The opportunity is listed under the Science and Technology and other Research and Development category.
What is the CFDA number for this program?
The CFDA number listed for this opportunity is 12.420.
Who administers the award?
The opportunity is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of Defense.
What award mechanisms may be used?
Funding may be provided as either a cooperative agreement or a grant. This suggests there may be different levels of government involvement depending on which mechanism is used for a given award.
What is the difference between a cooperative agreement and a grant in this listing?
The summary indicates that applicants should be prepared for varying levels of government involvement depending on whether the funding is issued as a cooperative agreement or a grant, but it does not provide additional details beyond that statement.
Who is eligible to apply?
Eligibility is listed as unrestricted, which generally means a broad range of organization types may be eligible to apply, assuming no additional limitations appear elsewhere in the full announcement.
How many awards were anticipated?
The opportunity anticipated making two awards.
When was the opportunity originally posted?
The listing indicates it was originally posted on May 14, 2018.
What was the original closing date?
The original closing date shown is August 2, 2018.
Is there a stated maximum award amount (award ceiling)?
The listing shows an award ceiling of 0. This typically means a specific maximum amount was not provided in the summary field and would need to be confirmed in the full solicitation details.
What should applicants do if they need the actual funding limit?
Because the summary field shows an award ceiling of 0, the appropriate next step (based on the listing) would be to confirm the maximum funding level in the full solicitation details.
What kind of project structure seems most aligned with this award?
Projects most aligned with the description are those that explicitly connect laboratory and patient-focused components and show how results will feed back and refine the next stage of work, whether moving from preclinical to clinical (including a pilot trial when appropriate) or from clinical findings back into improved experimental models.
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