Opportunity Information: Apply for 75N99224R00001
Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx) is an ARPA-H funding opportunity focused on research and development aimed at identifying and advancing viral antigens with the potential to provide broad protection, using computational approaches as a central driver. The solicitation is issued by the Advanced Research Projects Agency for Health under Research and Development Solicitation No. 75N99224R00001, and it sits in the science and technology / R&D activity category (CFDA 93.384). The program framing signals an emphasis on ambitious, high-impact work that combines computational experimentation with downstream validation and development pathways, consistent with ARPA-Hs model of pushing toward actionable deliverables rather than purely exploratory studies.
The funding instrument listed for this opportunity is a cooperative agreement, which typically means substantial agency involvement is expected during performance, such as active program management, milestone tracking, and iterative technical direction. ARPA-H notes that it anticipates making multiple awards and that multiple award types may result from the announcement, suggesting the program may support a portfolio of performers working on different technical approaches, target virus families, modeling strategies, and validation pipelines.
The application process is structured in two stages and is not open proposal submission from the start. Applicants must first submit an abstract, and only those who submit an abstract can be considered for an invitation to submit a full proposal. Abstracts were due on December 15, 2023 at 9:00 AM Eastern Time. Full proposals are explicitly invite-only and were due on February 16, 2024 at 5:00 PM Eastern Time, which is also reflected as the original closing date in the source data. Eligibility is listed as unrestricted in the posting, but applicants are directed to the BAA/solicitation for the controlling eligibility and submission requirements.
ARPA-H encourages interested parties to review the attached APECx Research and Development Solicitation for full technical and administrative details, and to follow the opportunity posting for updates. Additional program context and public-facing information are available on the ARPA-H APECx program page at https://arpa-h.gov/engage/programs/apecx/. The posting also clarifies that the APEX Accelerators notice often shown on SAM.gov is a general small-business contracting resource message and is not related to the ARPA-H APECx program itself.Apply for 75N99224R00001
- The Advanced Research Projects Agency for Health in the science and technology and other research and development sector is offering a public funding opportunity titled "Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.384.
- This funding opportunity was created on 2023-11-21.
- Applicants must submit their applications by 2024-02-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Unrestricted.
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APECx (ARPA-H) Grant Opportunity FAQs
What is the APECx opportunity?
Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx) is an ARPA-H funding opportunity focused on research and development to identify and advance viral antigens that could provide broad protection. Computational approaches are positioned as the central driver, paired with downstream validation and development pathways.
Which federal agency is issuing this solicitation?
The solicitation is issued by the Advanced Research Projects Agency for Health (ARPA-H).
What is the official solicitation number for APECx?
The opportunity is under Research and Development Solicitation No. 75N99224R00001.
What category does this opportunity fall under?
The posting places APECx in the science and technology / research and development (R&D) activity category.
What is the CFDA number associated with this program?
The posting lists CFDA 93.384.
What kind of work is ARPA-H looking to support through APECx?
The framing emphasizes ambitious, high-impact R&D that uses computational experimentation to identify viral antigens with potential broad efficacy, and then connects that work to validation and development. The program model signals a push toward actionable deliverables rather than purely exploratory studies.
What is the funding instrument for this opportunity?
The listed funding instrument is a cooperative agreement.
What does a cooperative agreement imply for applicants and awardees?
In general, a cooperative agreement typically involves substantial federal involvement during the period of performance. The posting describes expectations such as active program management, milestone tracking, and iterative technical direction.
Does ARPA-H expect to make more than one award?
Yes. ARPA-H anticipates making multiple awards.
Can different award types come out of this announcement?
Yes. The notice states that multiple award types may result from the announcement, which suggests a portfolio approach supporting different performers and technical approaches.
Is the application process open submission of full proposals?
No. The process is structured in two stages and does not begin with open full proposal submission.
What is the first step to apply?
Applicants must first submit an abstract. Only parties that submit an abstract can be considered for an invitation to submit a full proposal.
Are full proposals invite-only?
Yes. Full proposals are explicitly invite-only.
When were abstracts due?
Abstracts were due on December 15, 2023 at 9:00 AM Eastern Time.
When were full proposals due?
Invite-only full proposals were due on February 16, 2024 at 5:00 PM Eastern Time. This date is also reflected as the original closing date in the source data.
Who is eligible to apply?
The posting lists eligibility as unrestricted, but it also directs applicants to the BAA/solicitation as the controlling source for eligibility and submission requirements.
Where should applicants look for the authoritative technical and administrative requirements?
Applicants are encouraged to review the attached APECx Research and Development Solicitation (the BAA/solicitation) for the full technical scope and administrative instructions.
Where can I find additional public information about the APECx program?
ARPA-H provides additional program context on the APECx program page at: https://arpa-h.gov/engage/programs/apecx/
Should applicants monitor the opportunity posting for updates?
Yes. The posting recommends following the opportunity listing for updates.
Is the "APEX Accelerators" notice on SAM.gov related to this ARPA-H program?
No. The posting clarifies that the APEX Accelerators notice commonly displayed on SAM.gov is a general small-business contracting resource message and is not related to the ARPA-H APECx program.
What kinds of approaches might be supported under a multi-award portfolio?
The notice suggests a portfolio of performers that could span different technical approaches, target virus families, modeling strategies, and validation pipelines, consistent with the program's computational experimentation focus and downstream development emphasis.
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